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EMBO Member

Sebastian Glatt

Jagiellonian University, Krakow | Poland

EMBO 2024

tRNAs and gene expression control

My research aims to reveal the molecular mechanisms that lead to the specific base modifications in tRNAs. The attachment of small chemical groups influences the efficiency and accuracy of the codon-anticodon pairing in the ribosome and therefore regulates the translational rates and folding dynamics of protein synthesis. Alterations of these modification pathways play important roles in the onset of certain neurodegenerative diseases and cancer.

Keywords: RNA modifications / epitranscriptomics / tRNA / translation / structural biology / neurodegenerative diseases

Subject area(s): Systems Biology | Structural Biology & Biophysics | RNA