Mutational mechanisms and clinical applications
My group explores mutational signatures and cellular physiological changes that lead to age-related phenomena such as cancer and neurodegenerative phenotypes. We use combinations of computational and experimental methods to explore how DNA damage and DNA repair affect human cells. We also develop clinical algorithmic tools and seek applications for our expertise in holistic cancer genome profiling in clinical contexts.
Keywords
Mutagenesis / mutational signatures / early detection / clinical algorithms / whole genome profiling