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EMBO Member

Serena Nik-Zainal

MRC Cancer Unit, Cambridge | United Kingdom

EMBO 2020

Mutational mechanisms and clinical applications

My group explores mutational signatures and cellular physiological changes that lead to age-related phenomena such as cancer and neurodegenerative phenotypes. We use combinations of computational and experimental methods to explore how DNA damage and DNA repair affect human cells. We also develop clinical algorithmic tools and seek applications for our expertise in holistic cancer genome profiling in clinical contexts.

Keywords: Mutagenesis / mutational signatures / early detection / clinical algorithms / whole genome profiling

Subject area(s): Genome Stability & Dynamics | Genomic & Computational Biology | Molecular Medicine