Cell growth, division and differentiation
My group is interested in understanding how cells coordinate cell growth and division with cell differentiation. In particular, we focus our attention (1) on the connection between TOR and the Cdk/cyclin complexes and (2) on the function of the anaphase promoting complex or cyclosome (APC/C) in cell differentiation. We use the fission yeast Schizosaccharomyces pombe as a unicellular model organism and the mouse as a multicellular system.
Keywords
Cell cycle / mitosis / meiosis / proteolysis / APC