Uncovering mechanism of cancer therapy resistance
Our primary goals are to identify the mechanism of relapse to targeted therapy by studying tumor intrinsic and tumor extrinsic mechanisms. We are performing multi-dimensional studies involving mitochondrial outer membrane potential measurements, multi-omics, and DNA barcoding to model drug-tolerant persisters. We are exploiting human blood cancer cell lines, patient-derived xenograft models, and primary tumors to address our hypothesis.
Keywords
Apoptosis / acute leukemia / personalized therapy / drug resistance modeling / BCL-2 family proteins / drug-tolerant persisters