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EMBO Global Investigator

Shruti Bhatt

National University (NUS), Singapore | Singapore

GIN 2023–2026

Uncovering mechanism of cancer therapy resistance

Our primary goals are to identify the mechanism of relapse to targeted therapy by studying tumor intrinsic and tumor extrinsic mechanisms. We are performing multi-dimensional studies involving mitochondrial outer membrane potential measurements, multi-omics, and DNA barcoding to model drug-tolerant persisters. We are exploiting human blood cancer cell lines, patient-derived xenograft models, and primary tumors to address our hypothesis.

Keywords: Apoptosis / acute leukemia / personalized therapy / drug resistance modeling / BCL-2 family proteins / drug-tolerant persisters

Subject area(s): Chromatin & Transcription | Differentiation & Death | Immunology | Signal Transduction