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EMBO Member

Simona Parrinello

University College London | United Kingdom

EMBO 2026

Initiation and early recurrence in brain cancer

My group studies cancer initiation and recurrence following treatment. We explore how the interplay between driver mutations in neural progenitor cells and activation of tissue injury responses promotes initiation and whether these mechanisms are reactivated in early recurrence. We focus on glioblastoma, the most common and aggressive type of primary brain cancer, with the goal of identifying more effective treatment strategies.

Keywords: Glioma / neural stem cells / microenvironment / tissue injury / cancer initiation / cell-cell signalling / invasion

Subject area(s): Cell & Tissue Architecture | Molecular Medicine | Neuroscience

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