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EMBO Member

Simona Polo

Istituto FIRC, Milano | Italy

EMBO 2016

Ubiquitin (de)regulation of signaling pathways

Our laboratory is interested in understanding the role of ubiquitin in regulating fundamental processes such as endocytosis, cell migration, and autophagy, in normal and pathological conditions. To establish how ubiquitination acts, it is critical to determine the type of ubiquitin modification and to understand the mechanism by which this signal is generated.

Keywords: Ubiquitin / signaling / HECT E3 ligase / structural biology / endocytosis / cancer

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics