Development of cryoEM methods
In my group we develop new methods for cryoEM structure determination. I introduced a Bayesian framework for single-particle analysis and implemented this in the open-source program RELION (http://www2.mrc-lmb.cam.ac.uk/relion). We also use structure determination projects on challenging samples to drive our methods development. In this context, we have solved structures of ribosomes, spliceosomes, gamma-secretase and other molecules.
Keywords
Cryo-EM / RELION / ribosome / spliceosome / gamma-secretase