EMBO Member
Sophie E. Polo
EMBO 2026
Former EMBO Young Investigator (2018)
Université Paris Cité, Paris, France
Epigenome maintenance in response to DNA damage
By studying chromatin plasticity in response to DNA damage, our main goal is to decipher how genome and epigenome maintenance are coordinated to preserve mammalian cell function and identity. We aim to identify the molecular players controlling histone dynamics, chromatin marks and higher-order structure following DNA damage. Reciprocally, we investigate how epigenome alterations impact genome stability in physio-pathological contexts.
Keywords
Chromatin / DNA repair / epigenetic marks / histones / genome integrity / oncogenesis