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EMBO Member

Sophie E. Polo

Université Paris Cité, Paris | France

EMBO 2026

Epigenome maintenance in response to DNA damage

By studying chromatin plasticity in response to DNA damage, our main goal is to decipher how genome and epigenome maintenance are coordinated to preserve mammalian cell function and identity. We aim to identify the molecular players controlling histone dynamics, chromatin marks and higher-order structure following DNA damage. Reciprocally, we investigate how epigenome alterations impact genome stability in physio-pathological contexts.

Keywords: Chromatin / DNA repair / epigenetic marks / histones / genome integrity / oncogenesis

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Molecular Medicine

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