Epigenetic regulation in development and disease
My research strives to further the understanding of mechanisms of epigenetic regulation through the study of X-chromosome inactivation and stochastic allelic gene expression during early mammalian development, using mouse/human embryos, germ cells and pluripotent stem cells, and extending that knowledge to epigenetic inheritance of diseases and providing therapeutic intervention.
Keywords
Epigenetics / X-chromosome inactivation / long non-coding RNA / naïve and primed pluripotency / primordial germ cells / transcriptional bursting / transgenerational epigenetic inheritance