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EMBO Global Investigator

Srimonta Gayen

Indian Institute of Science, Bangalore | India

GIN 2022–2025

Epigenetic regulation in development and disease

My research strives to further the understanding of mechanisms of epigenetic regulation through the study of X-chromosome inactivation and stochastic allelic gene expression during early mammalian development, using mouse/human embryos, germ cells and pluripotent stem cells, and extending that knowledge to epigenetic inheritance of diseases and providing therapeutic intervention.

Keywords: Epigenetics / X-chromosome inactivation / long non-coding RNA / naïve and primed pluripotency / primordial germ cells / transcriptional bursting / transgenerational epigenetic inheritance

Subject area(s): Chromatin & Transcription | Development | Genomic & Computational Biology | RNA