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EMBO Member

Stefan Mundlos

MPI for Molecular Genetics, Berlin | Germany

EMBO 2017

Gene regulation in development and disease

Our research interest focuses on fundamental questions of normal and abnormal development, in particular in regard to human diseases. We use the developing limb as a model system to study how gene regulation affects and controls morphogenesis. This includes 3D chromatin architecture, mechanisms of long-range regulation, as well as the function of cis-regulatory elements (enhancers) and their control by transcription factors.

Keywords: Gene regulation / chromatin conformation / limb development / congenital malformations / genetic disease

Subject area(s): Chromatin & Transcription | Development | Molecular Medicine