Normal and leukemic hematopoietic stem cell biology
We apply genetic tools and various molecular and functional single cell platforms to unravel the dynamics of normal stem and progenitor cells in unperturbed hematopoiesis and in response to distinct challenges, in mice and man. We also analyze and model the impact of recurrent genetic lesions at distinct stages of hematopoietic lineage commitment, to identify key cellular targets and molecular events in the transformation from normal to malignant hematopoiesis.
Keywords
Hematopoiesis / lymphopoiesis / stem cells / hematopoietic stem cells / hematopoietic progenitors / leukemic stem cells / myelodysplastic syndromes / lineage commitment