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EMBO Member

Stephan J. Sigrist

Freie Universit├Ąt Berlin | Germany

EMBO 2023

Organisation and dynamics of synaptic active zones

I seek to decipher how synapses, particularly their presynaptic active zones, assemble their protein architectures to support specific brain functions and behavioural adaptation. Thus, I adapt novel imaging techniques, particularly, super-resolution light microscopy (STED). I also analyse mechanisms of age-induced memory impairment, and thus could initiate the clinical testing of spermidine supplementation as an anti-brain-aging strategy.

Keywords: Neurodevelopment / super-resolution microscopy / synaptic plasticity / active zone / brain aging

Subject area(s): Neuroscience | Membranes & Transport | Development | Cell & Tissue Architecture | Cellular Metabolism | Neuroscience | Membranes & Transport | Development | Cell & Tissue Architecture | Cellular Metabolism | Neuroscience | Membranes & Transport | Development | Cell & Tissue Architecture | Cellular Metabolism

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