MIT, Cambridge | United States
We are studying hyperthermophilic archaea of the genus Sulfolobus. The information processing machineries of archaea are orthologous to, but simpler than, their eukaryotic counterparts. We principally focus on the DNA replication and cell division machineries and have exploited the simplicity and stability of the archaeal proteins to dissect their mode of action.
Keywords: DNA replication / evolution / archaea / chromatin / ESCRTs