EMBO Associate Member
1949 – 2016
Whitehead Institute, Cambridge (MA)
I have made protein folding a central focus in my study of normal biology and diseases, including cancer and neurodegeneration. We established that certain phenotypes in yeast are inherited through self-perpetuating protein conformations, called prions, and that chaperone proteins can affect the emergence and inheritance of new traits. We have also used yeast to create innovative model systems for studying complex diseases.
Keywords: Protein folding / heat-shock proteins / prions / chaperones / neurodegenerative disease / cancer / evolution