The function of long-range chromatin organization
We combined genetics and fluorescence microscopy to analyse nuclear organization in yeast and worms, determining the impact of chromatin subcompartments and domains on gene expression and DNA repair. We identified novel roles for checkpoint kinases, chromatin remodelers and ORC in genome stability, and showed that repeat expression destabilizes the genome in C. elegans. We identified novel nuclear envelope-tethering pathways in worms and yeast.
Keywords
Nuclear organization / heterochromatin / C. elegans / yeast / epigenetics / double-strand break repair / DNA replication