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EMBO Member

Susan M. Gasser

Friedrich Miescher Institute, Basel | Switzerland

EMBO 1993 | CouC 95–98 | Council 00–04

Heritable repression of genes and genome stability

We pioneered a combined genetic and fluorescence microscopy analysis of nuclear organization in budding yeast and examined its impact on heritable gene repression. In parallel, we have identified novel roles for RecQ helicases, checkpoint kinases, chromatin remodelers and ORC in genome stability. In recent years we studied the role of nuclear organization in the heritable repression of differentiation specific genes in C. elegans.

Keywords: Nuclear organization / heterochromatin / C. elegans / yeast / epigenetics / double-strand break repair / DNA replication

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Genomic & Computational Biology