Friedrich Miescher Institute, Basel | Switzerland
EMBO 1993 | CouC 95–98 | Council 00–04
We pioneered a combined genetic and fluorescence microscopy analysis of nuclear organization in budding yeast and examined its impact on heritable gene repression. In parallel, we have identified novel roles for RecQ helicases, checkpoint kinases, chromatin remodelers and ORC in genome stability. In recent years we studied the role of nuclear organization in the heritable repression of differentiation specific genes in C. elegans.
Keywords: Nuclear organization / heterochromatin / C. elegans / yeast / epigenetics / double-strand break repair / DNA replication