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EMBO Associate Member

Tadatsugu Taniguchi

University, Tokyo | Japan

EMBO 2018

Regulation of immunity, inflammation and cancer

My work concerns the mechanisms of signal transduction and gene expression that underlie immunity and oncogenesis. After the original discovery of two cytokine genes, the IFN-beta and IL-2 genes, we also discovered the IRF family of transcription factors, which play integral roles in the regulation of immunity and cancer. We also work on Damage-Associated Molecular Patterns (DAMPs) for their roles in inflammation-associated diseases and cancer.

Keywords: Innate immunity / IRF transcription factors / cancer immunology / HMGB1 / DAMPs

Subject area(s): Chromatin & Transcription | Immunology | Molecular Medicine | Signal Transduction