Regulation of immunity, inflammation and cancer
My work concerns the mechanisms of signal transduction and gene expression that underlie immunity and oncogenesis. After the original discovery of two cytokine genes, the IFN-beta and IL-2 genes, we also discovered the IRF family of transcription factors, which play integral roles in the regulation of immunity and cancer. We also work on Damage-Associated Molecular Patterns (DAMPs) for their roles in inflammation-associated diseases and cancer.
Keywords
Innate immunity / IRF transcription factors / cancer immunology / HMGB1 / DAMPs