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EMBO Young Investigator

Thi Hoang Duong Nguyen

MRC LMB, Cambridge | United Kingdom

YIP 2023–2026

Molecular mechanisms of telomere maintenance

Telomeres are nucleoprotein structures at the ends of eukaryotic chromosomes that protect the chromosome ends from degradation and inter-chromosome fusion. Telomeres are thus essential for maintaining genome stability. Telomere dysfunction has been implicated in cancers and aging. My laboratory aims to understand the molecular mechanisms and the regulation of telomere maintenance, and how disease mutations give rise to dysfunctional telomeres.

Keywords: Telomeres / telomerase / cryo-EM / ribonucleoprotein / biochemistry

Subject area(s): Genome Stability & Dynamics | Proteins & Biochemistry | RNA | Structural Biology & Biophysics