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EMBO Associate Member

Thomas J. Silhavy

Princeton University | United States

EMBO 2008

Outer membrane biogenesis

Using Escherichia coli, my lab was the first to isolate signal sequence mutations, to identify a component of the protein secretion and outer membrane assembly machineries, and to identify a two-component regulatory system. Current work focuses on the mechanisms of outer membrane biogenesis and the regulatory systems that sense and respond to envelope stress and trigger entry into stationary phase.

Keywords: Membrane biogenesis / protein targeting / lipopolysaccharide transport / stress responses / E. coli

Subject area(s): Membranes & Transport | Microbiology, Virology & Pathogens | Signal Transduction