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EMBO Member

Thomas M. Jovin

MPI for Multidisciplinary Sciences, Göttingen | Germany

EMBO 1981 | CouC 93–96

Protein interactions with left-handed DNA during the cell cycle

My emeritus lab is currently engaged in studies of the interactions, and significance thereof, of DNA topoisomerase (and functionally related proteins) with left-handed double-helical DNA (Z-DNA). The methods employed employ bioinformatics, biophysics (kinetics, thermodynamics, imaging), molecular biology, and cell biology. We are also engaged in collaborations related to new methods for high-resolution fluorescence microscopy.

Keywords: Nucleic acid conformation / DNA topoisomerase / signal transduction / cell biophysics / advanced optical probes / high resolution microscopy / neurodegenerative disease / Parkinson's disease / alpha-synuclein

Subject area(s): Cell & Tissue Architecture | Molecular Medicine | Proteins & Biochemistry | Structural Biology & Biophysics