EMBO Member
Thomas M. Jovin
EMBO 1981 | CouC 93–96
MPI for Multidisciplinary Sciences, Göttingen, Germany
Protein interactions with left-handed DNA during the cell cycle
My emeritus lab is currently engaged in studies of the interactions, and significance thereof, of DNA topoisomerase (and functionally related proteins) with left-handed double-helical DNA (Z-DNA). The methods employed employ bioinformatics, biophysics (kinetics, thermodynamics, imaging), molecular biology, and cell biology. We are also engaged in collaborations related to new methods for high-resolution fluorescence microscopy.
Keywords
Nucleic acid conformation / DNA topoisomerase / signal transduction / cell biophysics / advanced optical probes / high resolution microscopy / neurodegenerative disease / Parkinson's disease / alpha-synuclein