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EMBO Member

Thorsten Hoppe

Universität, Köln | Germany

EMBO 2020

Physiological regulation of protein homeostasis

My group investigates the regulation of protein homeostasis from molecular mechanisms to physiology and disease. We particularly focus on the ubiquitin/proteasome-system using C. elegans as model organism. We employ innovative in-vitro and in-vivo protein degradation assays, microscopical, optogenetic, and chemosensation methods, which allow the identification of conserved, tissue-specific and organismal protein homeostasis mechanisms.

Keywords: Ubiquitin chain formation / protein homeostasis / protein aggregation / mechano-stress & muscle function / organismal regulation / aging / chromatin-associated degradation

Subject area(s): Cellular Metabolism | Development | Proteins & Biochemistry