Nuclear proteomics & gene expression in cancer
My group aims at deciphering the biological role of chromatin dynamics, histone modifications and epigenetic enzymes and their impact on cancer progression and plasticity. We do this undertaking an integrative -omics strategy centred on quantitative mass spectrometry and applied both to pre-clinical models and to clinical patient samples.
Keywords
Mass spectrometry / proteomics / histone post-translational modification / epigenetics / protein methylation / epigenetic drugs / cancer / drug target deconvolution