EMBO Member
Tom Owen-Hughes
EMBO 2007
Former EMBO Young Investigator (2001)
University, Dundee, United Kingdom
Chromatin structure and function
We are interested in how chromatin structure is regulated to allow genes to be expressed correctly. A special interest is the action of ATP-dependent chromatin remodelling enzymes. We use both genomic and structural approaches to study their mechanism of action. Ongoing projects are aimed at understanding how human SWI/SNF complexes act in cancer.
Keywords
Chromatin remodelling / histone modifications / epigenetics / nucleosome structure / Snf2 proteins