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EMBO Member

Tom Owen-Hughes

University, Dundee | United Kingdom

EMBO 2007

Chromatin structure and function

We are interested in how chromatin structure is regulated to allow genes to be expressed correctly. A special interest is the action of ATP-dependent chromatin remodelling enzymes. We use both genomic and structural approaches to study their mechanism of action. Ongoing projects are aimed at understanding how human SWI/SNF complexes act in cancer.

Keywords: Chromatin remodelling / histone modifications / epigenetics / nucleosome structure / Snf2 proteins

Subject area(s): Chromatin & Transcription | Genomic & Computational Biology | Structural Biology & Biophysics