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EMBO Associate Member

Tony Hunter

Salk Institute for Biological Studies, La Jolla | United States

EMBO 1992

We are using 1-and 3-pHis specific mAbs to study histidine phosphorylation of proteins and identify new pHis-containing proteins, and to investigate possible roles for histidine phosphorylation in cancer. We are investigating crosstalk between stromal cells and tumor cells in the pancreatic TME, focusing on cytokines, such as LIF and OSM, secreted by cancer-associated fibroblasts and myeloid cells that may be important for tumor progression

Keywords: Signal transduction / protein phosphorylation / cell cycle checkpoints / protein ubiquitylation / cell transformation

Subject area(s): Cell Cycle | Molecular Medicine | Signal Transduction