EMBO Associate Member
Tony Hunter
EMBO 1992
Salk Institute for Biological Studies, La Jolla, United States
We are using 1-and 3-pHis specific mAbs to study histidine phosphorylation of proteins and identify new pHis-containing proteins, and to investigate possible roles for histidine phosphorylation in cancer. We are investigating crosstalk between stromal cells and tumor cells in the pancreatic TME, focusing on cytokines, such as LIF and OSM, secreted by cancer-associated fibroblasts and myeloid cells that may be important for tumor progression
Keywords
Signal transduction / protein phosphorylation / cell cycle checkpoints / protein ubiquitylation / cell transformation