EMBO Member
Ueli Schibler
EMBO 1988
University, Geneva, Switzerland
Circadian gene expression and physiology
My lab was studying the molecular basis of circadian rhythms in mammals, using mice and cultured cells as model systems. Our reserach was focussed on how the master pacemaker in the brain's suprachiasmatic nucleus synchronizes peripheral circadian oscillators in nearly all body cells and suggests that this is accomplished by feeding rhythms (driven by rest activity cycles), body temperature rhythms, and diurnal blood-borne signals.
Keywords
Circadian gene expression / mammalian cells / peripheral clocks / synchronization / posttranscriptional regulation