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EMBO Member

Ueli Schibler

University, Geneva | Switzerland

EMBO 1988

Circadian gene expression and physiology

My lab was studying the molecular basis of circadian rhythms in mammals, using mice and cultured cells as model systems. Our reserach was focussed on how the master pacemaker in the brain's suprachiasmatic nucleus synchronizes peripheral circadian oscillators in nearly all body cells and suggests that this is accomplished by feeding rhythms (driven by rest activity cycles), body temperature rhythms, and diurnal blood-borne signals.

Keywords: Circadian gene expression / mammalian cells / peripheral clocks / synchronization / posttranscriptional regulation

Subject area(s): Cellular Metabolism | Chromatin & Transcription | Signal Transduction