Yeast meiotic and somatic homologous recombination
My lab studies how cells repair the double-strand breaks deliberately induced during meiosis, by homologous recombination. This step is essential for the accurate segregation of homologous chromosomes, and therefore for obtaining gametes (eggs or sperm) with a normal chromosome content, preventing aneuploidy at the source of chromosomal diseases or infertility.
Keywords
Meiosis / DNA double-strand break repair / homologous recombination / chromosome structure / chromatin / genomic studies