EMBO Member
Veronica van Heyningen
EMBO 2002 | MemC 05–08 | Council 10–10 | Council 11–13 | Council 14–14
University College London, United Kingdom
Eye development genes, networks and modifiers
Study of human eye malformations to identify genes implicated in eye development. Defining the role of these genes, mostly eye/brain transcription factors (eg PAX6, SOX2, OTX2) and major signalling molecules (eg SHH), in mice and zebrafish. Exploration of cis-regulatory control mechanisms to identify upstream regulators and downstream targets and generate gene regulatory networks. Study of mechanisms of phenotype modulation.
Keywords
Human disease genetics / eye anomalies / cis-regulation of gene expression / gene-environment interaction / genome evolution