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EMBO Member

Vincent Colot

Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Paris | France

EMBO 2010

Genome dynamics and epigenetic variation

We study the contribution of chromatin-based epigenetic processes to heritable phenotypic variation. As TE sequences are associated with most of the known cases of epimutable alleles in plants and mammals, we focus on this typically neglected component of genomes and on the factors that control their epigenetic state and activity as well as their impact on adjacent genes. We use primarily the plant Arabidopsis and (epi)genomic approaches.

Keywords: Epigenetics / DNA methylation / transposable elements / epigenomics / Arabidopsis / natural variation

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Genomic & Computational Biology | Plant Biology