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Portrait of Vincenzo Costanzo

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Vincenzo Costanzo

EMBO 2024

Former EMBO Young Investigator (2007)

Istituto Firc di Oncologia Molecolare, Milano, Italy

DNA replication and repair in vertebrates

My group examines the roles of vertebrate DNA metabolism genes in cell cycle, DNA replication and DNA repair in unchallenged and stressful conditions. We discovered that RAD51 prevents ssDNA gap accumulation and Mre11 nuclease-mediated nascent DNA degradation, showed the role of BRCA1/2 in preventing gap accumulation and extensive DNA degradation from SMARCAL1-induced fork reversal and identified Pol Theta's role in gap filling and preventing replication fork rupture.

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DNA repair / DNA replication / DNA damage response / DNA gaps / DNA recombination / Xenopus laevis

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ORCID profile ↗Vincenzo Costanzo on EMBO’s Science Map