Structural basis of splicing regulation
We explore the structural basis of splicing regulation, with respect to (i) the coupling between splicing, the chromatin landscape and downstream processing events, as well as (ii) splicing modulation by cancer-causing mutations and by compounds with cytostatic effects. We employ single-particle electron cryomicroscopy, X-ray crystallography, complementary biochemical studies and various functional assays.
Keywords
Pre-mRNA splicing / chromatin / polyadenylation / alternative splicing / cancer biology / gene expression