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EMBO Young Investigator

Vladimir Pena

MPI für biophysikalische Chemie, Göttingen | Germany

YIP 2018

Structural basis of splicing regulation

We explore the structural basis of splicing regulation, with respect to (i) the coupling between splicing, the chromatin landscape and downstream processing events, as well as (ii) splicing modulation by cancer-causing mutations and by compounds with cytostatic effects. We employ single-particle electron cryomicroscopy, X-ray crystallography, complementary biochemical studies and various functional assays.

Keywords: Pre-mRNA splicing / chromatin / polyadenylation / alternative splicing / cancer biology / gene expression

Subject area(s): Proteins & Biochemistry | RNA | Structural Biology & Biophysics