EMBO Global Investigator
My lab has a long-standing interest in understanding the epigenetic mechanisms of lineage plasticity in early development. More recently, we have broadened our investigations to study how cancer cells undergo epigenetic reprogramming to induce phenotypic plasticity. This cross-fertilisation strategy has been rewarding, directing us to uncover conserved mechanisms implicated in epigenetic reprogramming and exposing novel cancer vulnerabilities.
Keywords: Chromatin / reprogramming / stem cells / cancer