EMBO Member
William C. Earnshaw
EMBO 1999 | CouC 08–09 | CouC 10–13 | TemC 10–10
Wellcome Centre for Cell Biology, Edinburgh, United Kingdom
Mitotic Chromosome Structure and Segregation
We study mitotic chromosome structure and segregation using proteomic, genetic and cell biology approaches. Our recent studies employing human synthetic artificial chromosomes highlight the importance of transcription and histone modifications for kinetochore assembly. We also study the 'chromosomal passenger complex' (INCENP, Aurora B kinase, Survivin and Borealin) a major regulator of mitosis and cytokinesis.
Keywords
Mitosis / condensin / chromosome structure / centromeres & kinetochores / gene knockouts in DT40 cells