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EMBO Member

Wim Vermeulen

Erasmus University MC, Rotterdam | Netherlands

EMBO 2021

DNA repair mechanisms and biological significance

My lab uses a multidisciplinary strategy to dissect the mechanism of nucleotide excision repair (NER) and its significance for human health: protecting against DNA damage-induced carcinogenesis and aging. We focus on NER regulation and its crosstalk with other DDR processes, transcription and replication. We aim to translate our fundamental knowledge towards improved diagnostic for DDR-deficiency disorders and to provide rationalized basis for precision cancer therapy.

Keywords: DNA damage response / chromatin / nucleotide excision repair / live cell imaging / human DNA repair syndromes / transcription stress / aging / cancer

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Molecular Medicine

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