DNA repair mechanisms and biological significance
My lab uses a multidisciplinary strategy to dissect the mechanism of nucleotide excision repair (NER) and its significance for human health: protecting against DNA damage-induced carcinogenesis and aging. We focus on NER regulation and its crosstalk with other DDR processes, transcription and replication. We aim to translate our fundamental knowledge towards improved diagnostic for DDR-deficiency disorders and to provide rationalized basis for precision cancer therapy.
Keywords
DNA damage response / chromatin / nucleotide excision repair / live cell imaging / human DNA repair syndromes / transcription stress / aging / cancer