Human cell proliferation and differentiation
My research focuses on how gene expression in human cells regulates cell proliferation and differentiation. To understand this regulation, my laboratory uses the human pathogen herpes simplex virus as a probe to elucidate mechanisms of combinatorial action of viral and cellular regulatory proteins. These studies elucidate the interplay of sequence-specific regulators and chromatin-modifying activities in the regulation of gene expression.
Keywords
Cell cycle / chromatin / transcription / herpes simplex virus / cancer