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EMBO Member

Wolf Reik

Babraham Institute, Cambridge | United Kingdom

EMBO 2003

Epigenetic reprogramming in mammalian development

Our lab is interested in epigenetic reprogramming in mammalian development. We study the mechanisms of genome-wide erasure of epigenetic marks in germ cells and early embryos, particularly the erasure of DNA methylation. We are exploring the biological significance of reprogramming in imprinting, pluripotency, transgenerational epigenetic inheritance, and transposon control. We apply these biological insights to stem cells and human health.

Keywords: Epigenetics / imprinting / developmental genetics / reprogramming / DNA methylation / ageing

Subject area(s): Chromatin & Transcription | Development | Genomic & Computational Biology