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EMBO Member

Xin Lu

Ludwig Institute for Cancer Research, Oxford | United Kingdom

EMBO 2011

Molecular mechanisms of cell fate determination

My group investigates how signals from the cell surface are integrated into the nucleus to make a cell fate decision. This has led to the identification of the ASPP family of proteins as regulators of cell adhesion and transcription. Our recent discovery of a novel nuclear import pathway, RaDAR, enabled us to investigate ankyrin repeat signalling in human disease including cancer.

Keywords: p53 / cell death / tumour suppression / signalling pathways / cell polarity / gene expression

Subject area(s): Differentiation & Death | Molecular Medicine | Signal Transduction