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EMBO Global Investigator

Yasunori Saheki

NTU Lee Kong Chian School of Medicine, Singapore | Singapore

GIN 2021–2025

Molecular basis of intracellular lipid transport

My lab studies the general principles of cellular lipid homeostasis and how these pathways are critical for neuronal and brain function. We focus on the molecular mechanisms that mediate intracellular transport of cholesterol and phospholipids, as their dysfunction is often linked to neurodegeneration. We employ a highly interdisciplinary approach that combines mammalian cell biology, biochemistry, and C. elegans genetics to tackle this challenge.

Keywords: Non-vesicular transport / lipid transfer proteins / membrane contact sites / cholesterol / phospholipids / endoplasmic reticulum / plasma membrane / neurons

Subject area(s): Cellular Metabolism | Membranes & Transport | Molecular Medicine | Neuroscience