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EMBO Associate Member

Yigong Shi

Westlake University, Hangzhou | China

EMBO 2013

Mechanistic investigation of RNA splicing and AD

My lab combines structural biology, biochemical, and biophysical approaches to investigate the molecular and chemical basis of fundamental cellular processes, with a particular interest in spliceosome-catalyzed pre-mRNA splicing, mechanism of regulated intramembrane proteolysis, and regulation of cell death.

Keywords: Macromolecular machineries / pre-mRNA splicing / nuclear pore complex / Alzheimer's disease / gamma-secretase / structural biology

Subject area(s): Membranes & Transport | Proteins & Biochemistry | RNA | Structural Biology & Biophysics