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EMBO Young Investigator

Yogesh Kulathu

University, Dundee | United Kingdom

YIP 2016–2019

Ubiquitin signalling mechanisms

The research goal of my lab is to discover the fundamental principles of how the posttranslational modification of proteins with ubiquitin and ubiquitin-like modifiers (UBLs) mediates signal transduction essential for maintaining cellular homeostasis. We use a multidisciplinary approach to gain mechanistic and functional insights into how ubiquitin and UBL signals are written, decoded and regulated to produce distinct cellular outcomes.

Keywords: Ubiquitin / UBL / deubiquitinase / structural biology / protein degradation / proteostasis / kinase / immune signalling / lymphocyte

Subject area(s): Immunology | Proteins & Biochemistry | Signal Transduction | Structural Biology & Biophysics