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EMBO Young Investigator

Yosef Buganim

Hebrew University, Jerusalem | Israel

YIP 2017

The molecular basis of cell fate decisions

My lab is interested in identifying the components (e.g. transcription factors, chromatin remodelers, epigenetic marks and metabolites) that determine cellular identity and the elements that can force cells to acquire an alternative fate. We study two major cell fate decision processes in the embryo: (i) Embryo vs placenta and (ii) sex determination. To that end we employ nuclear reprogramming, embryo manipulation and single-cell technologies.

Keywords: Embryonic stem cells / trophoblast stem cells / sex determination / reprogramming to pluripotency / direct conversion

Subject area(s): Chromatin & Transcription | Development