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EMBO Member

Yosef Shiloh

University, Tel Aviv | Israel

EMBO 2002 | FelC 06–09

The ATM-mediated DNA damage response: system and pathways

We are interested in the mechanisms that maintain genomic stability. Our work is focused on the ATM-mediated signaling network, which is activated by DNA damage. ATM is a powerful protein kinase that is absent in patients with the genomic instability syndrome, ataxia-telangiectasia (A-T). Another focus of interest in the lab is the molecular pathology of neurodegeneration in A-T.

Keywords: DNA damage response / genome stability / ATM / ataxia-telangiectasia / cell cycle checkpoints / genetic predisposition to cancer / aging

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Signal Transduction