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EMBO Member

Yosef Shiloh

University, Tel Aviv | Israel

EMBO 2002 | FelC 06–09

The ATM-mediated DNA damage response

We are interested in the mechanisms that maintain genome stability and the link between genome stability, human diseases and aging. Our work is focused on the ATM-mediated signaling network, which is activated by DNA damage. ATM is a powerful protein kinase that is absent in patients with the genome instability syndrome, ataxia-telangiectasia (A-T). We are also interested in the molecular pathology of the cerebellar degeneration in A-T.

Keywords: DNA damage response / genome stability / ATM / ataxia-telangiectasia / neurodegeneration / genetic predisposition to cancer / aging

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Signal Transduction