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EMBO Associate Member

Yoshinori Watanabe

University, Tokyo | Japan

EMBO 2014

Chromosome segregation in mitosis & meiosis

Our lab is interested in the molecular mechanisms regulating chromosome segregation in mitosis and meiosis. We have identified meiotic key factors, such as cohesin Rec8, cohesin protector shugoshin (SGO) and kinetochore protein Meikin. We show that SGO also regulates chromosome cohesion and bi-orientation in mitosis. We identified the causal link between SGO defects and chromosome instability in a wide range of cancer cell lines.

Keywords: Centromere / kinetochore / cohesion / meiosis / mitosis

Subject area(s): Cell Cycle | Genome Stability & Dynamics