EMBO Associate Member
University, Tokyo | Japan
Our lab is interested in the molecular mechanisms regulating chromosome segregation in mitosis and meiosis. We have identified meiotic key factors, such as cohesin Rec8, cohesin protector shugoshin (SGO) and kinetochore protein Meikin. We show that SGO also regulates chromosome cohesion and bi-orientation in mitosis. We identified the causal link between SGO defects and chromosome instability in a wide range of cancer cell lines.
Keywords: Centromere / kinetochore / cohesion / meiosis / mitosis