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EMBO Global Investigator

Yun Xia

Nanyang Technological University, Singapore | Singapore

GIN 2021–2025

Generate human kidney organoid from stem cells

Our lab is interested in developing a kidney organoid model that exhibits higher pathophysiological relevance to the cognate organ. To reconstruct the close-to-native kidney tissue microenvironment, we are employing single-cell transcriptomics, gene editing tools, and stem cell technologies to generate and reassemble the missing cell types into the current kidney organoid model.

Keywords: Kidney organoid / differentiation / self-organization / polycystic kidney disease / metabolic reprogramming

Subject area(s): Cell & Tissue Architecture | Development | Differentiation & Death