Structure of pathogen-associated protein machinery
My group has revealed fundamental insights into the replication/transcription, assembly, and host invasion mechanisms of important viruses such as coronavirus, retrovirus, influenza virus, picornavirus, herpesvirus, and Africa-Swine-Fever-virus. These studies have led to the development of new therapeutic agents for these diseases. We have also discovered how Mycobacterium tuberculosis achieves metabolite/energy transport and drug resistance.
Keywords
Virus / life cycle / replication / transcription / replication–transcription complex / assembly / host invasion